業績

2024年

Yamada T, Tanaka S, Noda T, Urashima K, Fujimoto A, Kohda Y, Kato R. Disproportionality analysis of flutamide- or bicalutamide-induced liver injury with and without steroids using the Japanese Adverse Drug Event Report database. Int J Clin Pharm. in press (2024).https://doi.org/10.1007/s11096-024-01814-x
Imano H, Hayashi T, Nomura A, Tanaka S, Kohda Y, Yamaguchi T, Izumi Y, Yoshiyama M, Hirose Y, Ohta-Ogo K, Ishibashi-Ueda H, Kato R. Suppressing the expression of steroidogenic acute regulatory protein (StAR) in the myocardium by spironolactone contributes to the improvement of right ventricular remodeling in pulmonary arterial hypertension. Hypertens Res. in press (2024).https://doi.org/10.1038/s41440-024-01908-z
Asai H, Kato K, Miyasaka M, Hatsukawa K, Murakami N, Takeda N, Abe J, Aoyagi Y, Kohda Y, Gui MY, Jin YR, Li XW, Hitotsuyanagi Y, Takeya K, Andoh T, Kurosaki H, Fukuishi N. Kamebakaurin suppresses antigen-induced mast cell activation by inhibition of FcεRI signaling pathway. Int Arch Allergy Immunol.185, 836-847 (2024). https://doi.org/10.1159/000536334
Tanaka S, Noda T, Urashima K, Kohda Y, Ijiri Y, Kato R. Reactive metabolite of trovafloxacin activates inflammasomes: implications for trovafloxacin-induced liver injury. J Appl Toxicol. 44, 846-852 (2024).https://doi.org/10.1002/jat.4585

2023年

Nakahari T, Suzuki C, Kawaguchi K, Hosogi S, Tanaka S, Asano S, Inui T, Marunaka Y. Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca²⁺ Channel, Cav1.2, via pH_i Increase and [Cl^–]_i Decrease in the Lung Airway Epithelial Cells of Mice. Int J Mol Sci. 24, 16976 (2023).https://doi.org/10.3390/ijms242316976
Kato R, Yamada T, Noda T, Tanaka S, Kohda Y, Ijiri Y. Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes. Toxicol In Vitro. 90, 105606 (2023).https://doi.org/10.1016/j.tiv.2023.105606
Yamada T, Kato R, Ijiri Y, Nishihara M, Neo M. Disproportionality analysis of acetaminophen-induced hepatic disorders with and without immune checkpoint inhibitors. Int J Clin Pharm. 45, 442-450 (2023).https://doi.org/10.1007/s11096-022-01527-z
Ichihashi A, Inamoto T, Uchimoto T, Nakamura KO, Komura K, Yano Y, Nishimura K, Kinoshita S, Nishio K, Fukushima T, Nakamori K, Matsunaga T, Tsutsumi T, Tsujino T, Uehara H, Takahara K, Yamamoto K, Kato R, Ijiri Y, Hayashi T, Azuma H. Tissue Distribution of Cisplatin by Intra-arterial Infusion Route in Comparison to Systemic Route: Implication to Therapy for Node-positive Bladder Cancer. In Vivo. 37, 143-148 (2023).https://doi.org/10.21873/invivo.13063
Yokoe S, Hayashi T, Nakagawa T, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Yoshiyama M, Asahi M. Augmented O-GlcNAcylation exacerbates right ventricular dysfunction and remodeling via enhancement of hypertrophy, mitophagy, and fibrosis in mice exposed to long-term intermittent hypoxia. Hypertens Res. 46, 667-678 (2023).https://doi.org/10.1038/s41440-022-01088-8
Hosogi S, Kuwahara A, Kuwahara Y, Tanaka S, Shimamoto C, Tagawa N, Kato I, Yoshimoto K, Aoi W, Takata K, Miyazaki H, Niisato N, Tsubo Y, Yagi K, Nakahari T, Marunaka Y. Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus. Biomed Res. 44, 17-29 (2023).https://doi.org/10.2220/biomedres.44.17
Saito D, Suzuki C, Tanaka S, Hosogi S, Kawaguchi K, Asano S, Okamoto S, Yasuda M, Hirano S, Inui T, Marunaka Y, Nakahari T. Ambroxol-enhanced ciliary beating via voltage-gated Ca2+ channels in mouse airway ciliated cells. Eur J Pharmacol. 941,175496 (2023).https://doi.org/10.1016/j.ejphar.2023.175496
Kohda Y. Effects of continuous thiamine intake on onset and progression of type 2 diabetes in leptin-receptor deficient mice. Fundam. Toxicol Sci. 10, 83-90 (2023).https://doi.org/10.2131/fts.10.83

2022年

Noda T, Kato R, Ozato Y, Kawai Y, Yamamoto M, Kagawa Y, Azuma M, Yamamoto K, Kusanagi M, Uryu K, Harada H, Ijiri Y, Hayashi T, Tanaka K. Decreased Plasma Acetaminophen Glucuronide/Acetaminophen Concentration Ratio warns the onset of Acetaminophen-Induced Liver Injury. Biopharm Drug Dispos. 43, 108-116 (2022).https://doi.org/10.1002/bdd.2316
Kato R, Ijiri Y. Regorafenib and reactive metabolite of sunitinib activate inflammasomes: Implications for multi tyrosine kinase inhibitor-I iduced immune related adverse events. Pharmazie. 77, 54-58 (2022).https://doi.org/10.1691/ph.2022.1955
Noda T, Kato R, Hattori T, Furukawa Y, Ijiri Y. Tanaka K. Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury. Life Sci. 294, 120351 (2022).https://doi.org/10.1016/j.lfs.2022.120351

2021年

Kato R, Ijiri Y, Hayashi T. Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions. Chem Res Toxicol. 34, 1860−1865 (2021).https://doi.org/10.1021/acs.chemrestox.1c00127
Imano H, Kato R, Ijiri Y, Hayashi T. Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicol In Vitro. 71, 105063 (2021).https://doi.org/10.1016/j.tiv.2020.105063
Tanaka S, Ito S, Shimamoto C, Matsumura H, Inui T, Marunaka Y, Nakahari T. Nitric oxide synthesis stimulated by arachidonic acid accumulation via PPARα in acetylcholine-stimulated gastric mucous cells. Exp Physiol. 106, 1939-1949 (2021).https://doi.org/10.1113/EP089517
Kohda Y. Focus on orexin-A in obese diabetes rats: upregulation of orexin-A receptor in the diabetic brain. Fundam Toxicol Sci. 8, 235-241 (2021).https://doi.org/10.2131/fts.8.235

2020年

Imano H, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Nomura A, Yoshiyama M, Hayash T. Protease-Activated Receptor-1 Inhibition by FR171113 Attenuates Cardiac Remodeling Due to Intermittent Hypoxia. Ann Cardiol Vasc Med. 3, 1036 (2020).
Kato R, Ijiri Y, Hayashi T, Uetrecht J. Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 45, 673-680 (2020).https://doi.org/10.2131/jts.45.673

2019年

Nakagawa T, Furukawa Y, Hayashi T, Nomura A, Yokoe S, Moriwaki K, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Yoshiyama M, Asahi M. Augmented O-GlcNAcylation attenuates intermittent hypoxia-induced cardiac remodeling through the suppression of NFAT and NF-κB activities in mice., Hypertens Res. 42, 1858-1871 (2019).https://doi.org/10.1038/s41440-019-0311-x
Kato R, Ijiri Y, Hayashi T, Uetrecht J. The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions. Drug Metab Dispos. 47, 1093-1096 (2019).https://doi.org/10.1124/dmd.119.087981
Kato R, Sato T, Iwamoto A, Yamazaki T, Nakashiro S, Yoshikai S, Fujimoto A, Imano H, Ijiri Y, Mino Y, Chikuma M, Tanaka K, Hayashi T. Interaction of platinum agents, cisplatin, carboplatin and oxaliplatin against albumin in vivo rats and in vitro study using inductively coupled plasma-mass spectrometory. Biopharm Drug Dispos. 40, 242-249 (2019).https://doi.org/10.1002/bdd.2197